在1型糖尿病患者怀孕期间的葡萄糖控制与胎儿血液动力学相关:一项前性纵向研究
Patrik Simjak1,2, Katerina Anderlova3,4, Dagmar Smetanová2
1Clinic of Gynecology, Obstetrics and Neonatology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
BMC pregnancy and childbirth
|April 11, 2024
概括
母亲糖尿病会影响胎儿心脏发育. 1型糖尿病的葡萄糖控制不良与胎儿心脏结构和功能的改变有关,这影响了心和腹的参数.
科学领域:
- 心脏病学 心脏病学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 内分泌学 在内分泌学.
背景情况:
- 母亲糖尿病对胎儿心血管发育构成风险,导致结构和功能变化.
- 以前的研究还没有完全探索母亲的血糖控制和胎儿的心脏结果之间的联系.
- 这项研究调查了母亲血糖控制与胎儿心脏形态和功能在1型糖尿病中的关联.
研究的目的:
- 确定母亲血糖控制与胎儿心脏形态和功能在1型糖尿病 (T1DM) 怀孕期间之间的关联.
- 为了比较患有T1DM的母亲和健康对照的胎儿之间的胎儿心脏参数.
主要方法:
- 一项前性的纵向病例控制研究,涉及62名患有T1DM的孕妇和30名健康对照.
- 使用B模式,M模式和光谱脉冲波多普勒在第二和第三个季度进行胎儿心脏评估.
- 分析与胎儿心脏指数相关的孕产妇糖化血红蛋白,范围内的时间 (TIR),范围以下的时间 (TBR),范围以上的时间 (TAR) 和变化系数 (CV).
主要成果:
- 患有T1DM的母亲的胎儿显示左心室尺寸增加,心室间隔膜厚度,右心室输出和肺速度在28-32周.
- 肺和大动脉口径,心室中风体积和心脏输出与妊娠早期的葡萄糖可变性 (CV) 和糖化血红蛋白相反相关.
- 低血糖 (TBR) 和高血糖 (TAR) 分别与胎儿心脏功能受损有关,特别是腹参数和心功能.
结论:
- 怀孕期间的孕产妇高血糖症与受损的胎儿透气功能有关.
- 患有T1DM的母亲的葡萄糖变化和低血糖症与胎儿左心室缩功能降低有关.
- 这些发现凸显了母体葡萄糖管理对胎儿心血管健康的关键影响.
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