草对烧伤的影响:随机对照试验的系统审查和元分析
Yu-Ning Huang1, Kun-Chuan Chen2,3, Jen-Hung Wang4
1Department of Anesthesiology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, Taiwan.
概括
与其他局部治疗相比,草显著加快烧伤愈合. 然而,它在减少烧伤患者疼痛和预防感染方面的有效性仍然不确定.
科学领域:
- 皮肤病学和伤口护理
- 药理学 药理学是指药理学的学科.
- 基于证据的医学基于证据的医学.
背景情况:
- 烧伤带来了重大挑战,包括疼痛,感染风险和心理困扰.
- 是一种传统的药物,具有潜在的伤口愈合特性,但其对烧伤的疗效需要严格评估.
- 关于花对治疗烧伤患者的疼痛和预防感染的影响存在不确定性.
研究的目的:
- 系统地评估花对烧伤患者伤口愈合时间的影响.
- 评估在治疗疼痛和预防烧伤后感染方面的疗效.
- 为了确定阿洛韦拉在烧伤护理中的使用证据的质量.
主要方法:
- 在PubMed,Embase和CENTRAL的系统文献搜索随机对照试验 (RCT) 截至2023年10月9日.
- 使用Cochrane偏差风险评估工具 (版本2) 和用随机效应模型进行元分析进行偏差风险评估.
- 主要结局:伤口愈合时间. 二次结果:疼痛严重程度和伤口感染风险. 使用GRADE评估证据质量.
主要成果:
- 与其他局部治疗 (95% CI, -5.69至 -1.84) 相比,草显著减少了3.76天的平均伤口愈合时间.
- 在阿洛韦拉和对照组之间,没有发现疼痛减轻 (MD -0.76分;95% CI,-1.53至0.01) 或伤口感染风险 (RR 1.10;95% CI,0.34至3.59) 的显著差异.
- 包括9个RCT的数据,其中6个提供了主要结果的数据.
结论:
- 与其他局部药物相比,叶在二度烧伤中加速伤口愈合.
- 在烧伤患者中,与花的使用相关的感染风险没有增加.
- 阿洛韦拉对烧伤的止痛作用需要进一步研究.
相关概念视频
01:22Burn Injuries
2.5K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
2.5K
01:19Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
01:29Decreased Body Temperature
615
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
615