体重指数 (BMI) 较高对COVID-19后患者的认知功能和炎症的影响:二次分析
Gia Han Le1,2, Angela T H Kwan3,4, Ziji Guo2,4
1Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Acta neuropsychiatrica
|April 12, 2024
概括
通过高体重指数 (BMI) 表示的肥胖与后COVID-19状态 (PCC) 中更差的认知功能和更高的炎症有关. 体重指数升高可能会增加PCC风险和由于慢性炎症导致的认知缺陷.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 后COVID-19状态 (PCC) 呈现出持续的,影响多个器官系统的症状.
- 肥胖是PCC的潜在危险因素,可能由慢性系统性炎症介导.
- 认知功能障碍是PCC的常见症状,炎症可能起到作用.
研究的目的:
- 研究身体质量指数 (BMI) 对PCC患者认知功能的影响.
- 检查PCC患者的BMI和全身炎症标志物之间的关系.
- 在PCC的背景下探索BMI,认知功能和炎症之间的相互作用.
主要方法:
- 一个随机,双盲,安慰剂对照试验的后期分析,涉及70名PCC参与者.
- 分析了基线数据,以评估BMI和认知测试 (DSST,TMT-A/B) 之间的相关性.
- 血清中C-反应蛋白 (CRP) 和红细胞沉积率 (ESR) 的水平被用作炎症标志物.
主要成果:
- 在BMI和认知测试 (DSST,TMT-A,TMT-B) 的表现之间发现了显著的负相关性.
- 体重指数显示与血清CRP和ESR水平有显著的正相关性.
- 这些发现表明,较高的BMI与较差的认知功能和PCC炎症增加有关.
结论:
- 在PCC患者中,BMI和认知功能之间存在显著的负面关联.
- 在PCC中,BMI和全身炎症标志物 (CRP,ESR) 之间存在显著的积极关联.
- 结果表明BMI,PCC和认知功能之间存在双向关系,BMI升高可能会增加PCC风险,并通过慢性炎症增加认知障碍的严重程度.
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