基于宿主微生物群共同代谢分析的查,对症牛的潜在警告生物标志物进行查
Zhenlong Du1,2, Zhengzhong Luo1, Yixin Huang1
1Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Frontiers in microbiology
|April 12, 2024
概括
乳牛的症可以通过分析便和血胆酸以及肠道微生物群,在分娩前7天预测. 特定的胆汁酸和细菌变化表明症风险增加,允许早期干预.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 动物科学动物科学
- 代谢学 代谢学 代谢学
- 微生物组研究 微生物组研究
背景情况:
- 乳牛的症风险通常在分娩后使用血代谢物和行为来评估.
- 对于便胆酸和微生物群的产卵前变化,人们的了解有限.
- 在分娩前早期发现症风险对于及时干预至关重要.
研究的目的:
- 调查便胆汁酸概况的变化,并确定子在分娩前7天内发生症的潜在警告生物标志物.
- 为了分析肠道微生物群的组成与胆酸代谢的关系,在产牛前的奶牛.
- 通过代谢和微生物组分析,确定症风险的早期指标.
主要方法:
- 在过渡期内,监测了90头奶牛,在分娩前7天,分娩当天和分娩后7天采集了样本.
- 牛被分为症和健康的群体,基于分娩后血液β-基黄油酸水平.
- 代谢和16S rRNA amplicon序列测定是在选择的母牛的便和血样本上进行的,分娩前7天.
主要成果:
- 在产卵前7天,与能量相关的血清指数没有发现显著差异.
- 在症前组的便和血胆酸概况的特征是增加非结合的二次胆酸 (UnconSBA).
- 特定的便代谢物 (异氧化酸) 和细菌类 (例如,减少的* Oscillospiraceae* UCG-010,增加的 * Rikenellaaceae-RC9-gut-group*) 和血代谢物 (石化酸) 被确定为症的潜在预警生物标志物,在分娩前7天.
结论:
- 患有症风险的奶牛在分娩前7天表现出胆酸代谢障碍和肠道微生物组成的改变.
- 肠道微生物群的组成与胆酸代谢障碍密切相关,这表明它可能在症的发展中发挥作用.
- 需要进一步的研究来探索二次胆汁酸和症病原体之间的关系.
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