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通过3D免疫瘤模型对免疫检查点抑制剂的瘤反应的评估

Abdulmohammad Pezeshki^1,2, John C Cheville^1,3, Angela B Florio^1,2

¹Biomarker Discovery, Mayo Clinic, Rochester, MN, United States.

Frontiers in immunology

|April 12, 2024

概括

一种新的免疫瘤模型准确地预测了患者对免疫检查点抑制剂 (ICI) 和化疗等癌症疗法的反应,为个性化医学提供了一个有前途的工具.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物技术是生物技术.

背景情况:

在癌和膀癌中,患者对免疫检查点抑制剂 (ICI) 治疗的有限反应 (20%).
缺乏针对ICI治疗反应的预测测试.

研究的目的:

开发一种"免疫瘤"模型,以对瘤对ICI治疗的反应进行体外评估.
总结瘤微环境和免疫组件用于药物查.

主要方法:

从和膀癌中获得的患者衍生的球体 (免疫瘤).
免疫瘤菌的培养超过一个月,模仿瘤微环境.
实时监测药物反应 (ICI和化疗) 使用Incucyte和Cytotox红色染色.

主要成果:

从6/13个病例中建立了可行的免疫瘤模型,其中包含免疫和瘤细胞.
五个模型中的四个显示对化疗的有效性;五个模型中的两个对ICI有反应.
该模型在五分之三的病例中准确预测了临床反应.

结论:

免疫瘤模型有效地复制瘤微环境,用于临床前ICI查.
有潜力提供有关癌细胞,免疫系统和微环境相互作用的见解.
可行性研究需要更大的病例数和临床相关性来进一步验证.

关键词:

免疫检查点抑制剂 (ICI)这是一种免疫瘤类药物.微型癌症是一种微型癌症.患者衍生的瘤球形状球体.预测对免疫检查点抑制剂 (ICI) 治疗的反应.瘤透性淋巴细胞 (TILs) 是一种

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