患有自身免疫性疾病的人群中的心血管风险和炎症:叙事性综述
Camilla Bertoni1, Alessandra Mazzocchi2, Ludovica Leone3
1Department of Veterinary Sciences for Health, Animal Production and Food Safety, University of Milan, Milan, Italy.
Frontiers in immunology
|April 12, 2024
概括
青少年系统连接组织疾病 (JSCTD) 与脂质不良症和较高的心血管风险有关. 阿尔法-烯酸 (ALA) 补充剂可以改善脂质样本,并减少受影响儿童的炎症.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 青少年系统结合组织疾病 (JSCTD) 是一种慢性自身免疫性疾病.
- JSCTD与脱脂症和心血管风险增加有关.
- 自免疫性疾病中的炎症过程通常与脂质异常相关.
研究的目的:
- 为了分析患有JSCTD的儿童的脂质样本.
- 在JSCTD患者中评估心血管风险和动脉样硬化潜力.
- 调查皮质类固醇和免疫抑制剂等疗法对JSCTD失脂症的影响.
主要方法:
- 对2013年至2022年间发表的研究进行系统审查.
- 选择的研究侧重于小儿JSCTD患者的脂质样本.
- 分析JSCTD,脂质异常和心血管结果之间的关联.
主要成果:
- 在JSCTD患者表现出高甘油,总胆固醇 (TC-C) 和LDL-C,低HDL-C.
- 这些脂质特征异常会增加心肌梗塞,周围血管疾病,高血压和心房动的风险.
- 阿尔法-烯酸 (ALA) 补充剂在减少炎症标志物 (IL-6,CRP) 和失脂症患者的禁食葡萄糖方面表现有前途.
结论:
- 脱脂症是JSCTD的一个重大问题,导致心血管风险升高.
- 补充ALA可以通过调节自身免疫疾病中的炎症和脂质谱来提供治疗益处.
- 需要进一步研究ALA在控制JSCTD相关的脂质不良症和心血管风险方面的作用.
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