全免疫炎症值与腹腔大动脉化之间的关联:一个横截面研究
Chen Jin1, Xunjia Li2,3, Yuxiao Luo4
1Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in immunology
|April 12, 2024
概括
全免疫炎症值 (PIV) 与腹腔大动脉化 (AAC) 有积极的关联. 较高的PIV水平与AAC严重程度的增加相关,这表明PIV是PIV.
科学领域:
- 心血管研究研究心血管研究
- 炎症生物标志物 炎症生物标志物
- 医学成像分析 医学成像分析
背景情况:
- 腹腔大动脉化 (AAC) 的发病与炎症密切相关.
- 全免疫炎症值 (PIV) 是一个潜在的生物标志物,反映了系统性炎症,有助于疾病预后.
- 了解PIV和AAC之间的关系对于评估心血管健康至关重要.
研究的目的:
- 调查泛免疫炎症值 (PIV) 和腹腔大动脉化 (AAC) 之间的关联.
- 在AAC.的背景下探索PIV的预测能力.
- 使用PIV和其他临床因素开发和验证用于预测AAC和严重AAC (SAAC) 的模型.
主要方法:
- 对3047名参与者的国家健康和营养检查调查 (NHANES) 数据进行横截面分析.
- 使用加权多变量回归模型和趋势测试来评估PIV四分位数和AAC之间的关系.
- 拉索回归,多变量后勤回归,ROC曲线分析,校准图和决策曲线分析被用于模型开发和评估.
主要成果:
- 在PIV和AAC分数之间发现了显著的正相关性.
- 增加PIV四分位数与逐渐更高的AAC分数和严重AAC (SAAC) 的患病率增加有关.
- 对AAC和SAAC的预测模型显示出很好的准确性,AUC分别为0.74和0.84.
结论:
- 升高的PIV可能与AAC的存在和严重程度相关.
- 与简单的预测器相结合,PIV可能是一个有价值的工具,用于评估和管理AAC的个体.
- 进一步研究PIV在心血管疾病病原和预后中的作用是有必要的.
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