干白素抑制剂和与之相关的候群病风险
Sabir Khan1, Hazrat Bilal1, Muhammad Nadeem Khan2
1Department of Dermatology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Frontiers in immunology
|April 12, 2024
概括
干白素 (IL) 抑制剂可以增加对Candida感染的易感性. 医疗保健提供者应在开处方这些免疫调节疗法之前评估患者的风险概况,以预防候群病.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 互白蛋白 (ILs) 对于免疫调节和对抗疹等真菌感染至关重要.
- 抑制某些ILs,特别是IL-17和IL-23,与增加的Candida感染风险有关.
- IL抑制剂用于自身免疫性疾病,可能会改变对真菌的宿主防御.
研究的目的:
- 为了评估各种干白素 (IL) 抑制剂对坎迪达菌感染易感性的影响.
- 突出与不同类型IL抑制剂相关的候群病风险差异.
- 通知医疗保健提供者关于潜在的风险和监测的需要.
主要方法:
- 对现有文学和临床数据的审查IL抑制剂的使用和Candida感染.
- 在接受IL抑制剂治疗的患者中分析报道的候群病例和患病率数据.
- 在不同的IL抑制剂类 (IL-1,IL-2,IL-4,IL-6,IL-17,IL-23) 中比较候群病发病率.
主要成果:
- IL-1,IL-2和IL-4抑制剂与坎迪达菌感染的罕见关联.
- 在COVID-19治疗中使用托西利祖马布 (IL-6抑制剂) 显示,候选血症的患病率为6.9%.
- 与IL-23抑制剂相比,IL-17抑制剂与更高的Candida感染发病率有关.
结论:
- 医疗保健从业人员在开处方IL抑制剂时必须意识到候群病的风险.
- 特定的IL抑制剂,如托西利祖马布和IL-17抑制剂,需要提高警.
- 进一步的前性研究和监测对于安全有效的IL抑制剂使用至关重要.
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