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胃肠道微生物群在ME/CFS的发展中:一个批判性的观点和潜在的前景

Andreas Stallmach¹, Stefanie Quickert¹, Christian Puta^2,3,4

¹Department of Internal Medicine IV (Gastroenterology, Hepatology, and Infectious Diseases), Jena University Hospital, Jena, Germany.

Frontiers in immunology

|April 12, 2024

概括

SARS-CoV-2 感染可能导致肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS). 虽然肠道微生物群的变化与ME/CFS有关,但因果关系尚未被证明,但提供了潜在的治疗途径.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
神经学神经学

背景情况:

后急性感染综合征 (PAIS) 可以在SARS-CoV-2感染后发展,有时会发展为肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS).
ME/CFS是一种严重的多系统性疾病,其特点是运动后不适 (PEM),尽管怀疑神经,免疫和代谢变化,其病理生理学尚不清楚.
胃肠道微生物群在ME/CFS中的作用正在研究中,与免疫和炎症途径的潜在联系.

研究的目的:

审查目前关于胃肠道微生物群及其介质在ME/CFS中的变化的研究结果.
批判性地评估肠道失调和ME/CFS发展之间的因果关系的证据.
探索针对ME/CFS和其他PAIS的微生物群向治疗的潜力.

主要方法:

在ME/CFS患者中检查胃肠道微生物群组成和功能的研究文献综述.
对现有数据进行批判性分析,考虑到患者群体的异质性和研究局限性.
从其他胃肠道疾病中提取类比,以告知潜在的治疗策略.

主要成果:

在ME/CFS中,肠道微生物群组成和功能的变化经常被报告.
目前的证据主要显示肠道失调和ME/CFS之间存在关联,而不是因果关系.
研究通常涉及定义不良的患者群体,使解释复杂化.

结论:

虽然肠道失调与ME/CFS有关,但没有确立因果关系.
调节肠道微生物群和/或其代谢物是ME/CFS和PAIS的潜在治疗策略.
需要进一步的临床试验来研究这些针对微生物群的干预措施的有效性.

关键词:

在FMT和FMT中使用.ME/CFS 的意思是 ME/CFS.疲劳疲劳疲劳疲劳疲劳疲劳胃肠道的微生物群在后COVID时期.

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