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Updated: Jun 28, 2025

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
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In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

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解读组织居民Foxp3+调节性T细胞的发育轨迹

Fernando Alvarez1,2,3, Zhiyang Liu1,2,3, Alexandre Bay1,2,3

  • 1Department of Microbiology and Immunology, McGill University, Montréal, QC, Canada.

Frontiers in immunology
|April 12, 2024
PubMed
概括

调节性T细胞 (TREG) 通过表观遗传和转录性变化适应组织环境. 本综述探讨了它们的发育,组织居住和炎症反应,这些对免疫耐受性和修复至关重要.

关键词:
福克斯p3 + eTREG 细胞发展TREG的发展.这是一种炎症炎症炎症炎症.粘膜免疫力 粘膜免疫力两极分化是一种极化.组织居住地 组织居住地转录适应的转录适应

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T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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