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微生物群在类风湿性关节炎中的作用:一篇综述
Maria-Nefeli Tsetseri1, Alan J Silman1, David J Keene1,2
1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Rheumatology advances in practice
|April 12, 2024
概括
肠道疾病,肠道细菌的不平衡,可能会先于类风湿性关节炎 (RA) 的发展. 像Prevotella copri和Collinsela这样的特定细菌可能通过炎症和肠道屏障破坏促进RA的发病.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 人们越来越认识到肠道微生物组与免疫系统之间的复杂相互作用.
- 肠道疾病与各种系统性自身免疫性疾病的发展有关,包括类风湿性关节炎 (RA).
研究的目的:
- 批判性地审查和评估现有的小鼠和临床研究,调查肠道微生物组在类风湿性关节炎中的作用.
- 总结当前对 RA 发病过程中的肠道失生症的理解,并确定潜在的机制.
主要方法:
- 一个全面的文献综述6个小鼠研究和16个临床研究.
- 对发现的分析,以确定常见的微生物模式和在RA中提出的致病机制.
主要成果:
- 肠道失生症似乎在关节炎发作之前,局部肠道炎症可能会在易受感染的个体中引发全身炎症.
- 虽然没有确定确定的RA微生物组,但在早期RA中,Prevotella copri的过度存在以及Collinsela和某些Lactobacillus物种的扩散是常见的发现.
- 建议的机制包括炎症反应,P. copri的分子模仿,以及由于Collinsela的肠道屏障完整性受到损害.
结论:
- 肠道功能失调是类风湿性关节炎发病的潜在原因之一.
- 需要进一步进行大规模的纵向研究和临床试验,以阐明精确的机制,并探索针对RA的微生物组向治疗干预措施.
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