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在扩散MRI下方采样:一个捆绑特定的DTI和NODDI研究

Federico Spagnolo¹, Susanna Gobbi¹, Enikő Zsoldos¹

¹Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland.

Frontiers in neuroimaging

|April 12, 2024

概括

将扩散MRI (dMRI) 量减少高达30%,保持了从扩散张力成像 (DTI) 和神经元定向分散和密度成像 (NODDI) 的可比的白质微结构指标. 这种优化大大缩短了神经退行性疾病研究的获取时间.

科学领域:

神经成像是一种神经成像.
扩散磁共振成像 (dMRI) 是一种磁共振成像.
白物质微结构分析白物质微结构分析

背景情况:

多外dMRI对于表征神经退行性疾病中的白质至关重要.
非标准化的协议导致冗余测量和延长扫描时间.
优化dMRI获取对于大型临床研究至关重要.

研究的目的:

研究降低梯度方向对扩散张力成像 (DTI) 和神经元定向分散和密度成像 (NODDI) 度量的影响.
为了确定更短的dMRI协议的可行性,而不会损害数据完整性.

主要方法:

利用了三项纵向研究中124名健康对照者的dMRI数据.
开发了一种内部算法,以减少每个shell的梯度方向的数量.
估计DTI和NODDI对六个临床相关的白质捆绑的措施.

主要成果:

在30%的采样中,分数异位变异性 (FA) 和平均扩散性 (MD) 显示了最小的L1中位距离 (分别高达3.92%和4.31%).
在50%的抽样时,FA和MD的L1距离中位数分别为3.90%和5.49%.
细胞内体积分数 (ICvf) 在30%的采样中显示L1的中位距离高达2.83%.

结论:

在dMRI体积降低高达30%的情况下获得的DTI和NODDI指标与参考采样可比.
使用三个shell (4,14,和32个方向) 的优化协议显著减少了获取时间.
这些发现支持在大型临床研究中使用减少的dMRI协议来进行捆绑特异性扩散MRI分析.

关键词:

在 DTI 中,DTI 是指DTI.这就是为什么MRI是MRI.诺迪尔是什么意思收购时间收购时间神经退行性疾病的神经退行性疾病

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