布洛芬与乙胺相比,用于预防急性山病:一个随机的安慰剂控制试验
Srinivasa Bhattachar1,2, Vineet K Malhotra2, Uday Yanamandra3
1Physiology, High Altitude Medical Research Centre, Leh, IND.
Cureus
|April 12, 2024
概括
布洛芬有效地预防急性山病 (AMS) 在快速登期间男性. 虽然乙胺对严重的AMS更好,但易布洛芬提供了一个可行的替代品,副作用较少.
科学领域:
- 高度医学 高度医学
- 药理学 药理学是指药理学的学科.
- 预防医学 预防医学
背景情况:
- 乙胺是一种常见的AMS预防药物,但副作用限制了其使用.
- 之前的研究表明,在AMS预防方面,布洛芬的效果与乙醇胺相当或略低于乙胺.
研究的目的:
- 为了比较ibuprofen与acetazolamide在预防急性山病 (AMS) 的疗效.
- 评估易布洛芬作为AMS预防的替代品的安全性和有效性.
主要方法:
- 一项随机,三盲,安慰剂控制的试验,涉及304名健康的亚洲印度男性,迅速升至3500米.
- 参与者每天接受三次乙胺 (85毫克), (600毫克) 或安慰剂,从登山前一天开始.
- 使用路易斯湖问卷评估AMS发病率,并对生命体征进行监测.
主要成果:
- 艾布洛芬的AMS发病率为5%,而乙醇胺为12%,安慰剂为13% (治疗意图分析).
- 布洛芬显示出预防AMS的趋势 (相对风险为0.39与安慰剂相比,p=0.06).
- 乙胺在预防中度至重度的AMS方面表现出优越性.
结论:
- 布洛芬是有效的预防AMS在男性经历快速登到3500m.
- 在预防中度至重度的AMS方面,乙胺仍然优越.
- 布洛芬为AMS预防提供了一个潜在的有用替代品,特别是当乙醇胺是禁忌的.
相关概念视频
01:54The Placebo Effect
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
01:26Anxiolytic Drugs: Overview
Anxiolytic drugs are vital in managing anxiety disorders by effectively alleviating symptoms such as excessive fear, tachycardia, and tremors. There are several classes of anxiolytic medications, each with unique mechanisms of action and potential side effects.
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic circuitry.
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic circuitry.
01:29Anxiolytic Drugs: Benzodiazepines and Buspirone
Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABAA receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent...
01:25Antiasthma Drugs: β2-Adrenoceptor Agonists
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
01:19Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
01:21Drugs for Treatment of Constipation-Predominant IBS
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...