输血依赖和非输血依赖β-血病患者的骨病的大小
Rawand P Shamoon1,2,3, Ahmed K Yassin4,3, Negar Omar5
1Department of Pathology, College of Medicine, Hawler Medical University, Erbil, IRQ.
Cureus
|April 12, 2024
概括
伊拉克的依赖输血的β-thalassemia患者表现出明显较低的骨矿物质密度和较高的骨质疏松症比不依赖输血的患者. 骨密度与BMI和副甲状腺激素水平有关.
科学领域:
- 血液学 血液学 血液学
- 内分泌学 在内分泌学.
- 整形外科 整形外科 整形外科
背景情况:
- 贝塔血症是伊拉克北部普遍存在的一种遗传性血液疾病.
- 许多依赖输血 (TDT) 和非依赖输血 (NTDT) 的β-thalassemia患者经历了骨并发症.
- 评估骨病的严重程度对于管理这些患者至关重要.
研究的目的:
- 为了评估TDT和NTDTβ-thalassemia患者的骨病的程度.
- 为了比较TDT和NTDT患者组之间的骨矿物质密度 (BMD).
- 研究物理,生化和荷尔蒙因素对BMD的影响.
主要方法:
- 双能X射线吸收计 (DEXA) 扫描对53名TDT和20名NTDT患者 (年龄≥10岁) 进行了扫描.
- 在腰椎 (L1-L4) 和大腿部评估了骨状况.
- BMD Z-分数被用来确定骨病的严重程度,并分析了各种患者特征的相关性.
主要成果:
- 与NTDT患者 (分别为-2.05和-1.51) 相比,在腰椎 (-2.29) 和大腿部部 (-0.71) 的TDT患者中,BMD Z-score明显较低.
- 在腰椎骨质疏松的患病率在TDT患者 (69.8%) 显著高于NTDT患者 (40%) 在腰椎骨质疏松.
- 在两组中,BMD Z-score 与患者的身体质量指数 (BMI) 和副甲状腺激素 (PTH) 水平有显著的相关性.
结论:
- 在这个伊拉克队列中,高比例的β-thalassemia患者患有骨密度受损.
- 与不依赖输血的患者相比,依赖输血的β-thalassemia患者表现出更严重的骨病.
- 体重指数和PTH水平是这些患者与骨矿物质密度相关的重要因素.
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