新生儿重症监护病房中的微生物学特征和耐药性模式:一项回顾性监测研究
Sameh Kasem1, Ahmed Elhadidi2, Nuralhuda Omar2
1Pediatrics and Neonatology, Tawam Hospital, Al Ain, ARE.
Cureus
|April 12, 2024
概括
晚发性败血症 (LOS) 在新生儿中比早发性败血症 (EOS) 更常见. 目前的实证抗生素有效治疗新生儿败血症中常见的细菌感染,针对特定病原体观察到不同的耐药性模式.
科学领域:
- 新生儿传染病 新生儿传染病
- 临床微生物学 临床微生物学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 新生儿败血症仍然是全球疾病和死亡的重要原因.
- 了解致病原体的流行病学和抗微生物敏感性对于有效治疗至关重要.
研究的目的:
- 确定细菌感染在早期发作的败血症 (EOS) 和晚期发作的败血症 (LOS) 的流行率.
- 分析新生儿败血症中常见细菌分离物的抗微生物敏感性模式.
主要方法:
- 一项对新生儿的回顾性监测研究,这些新生儿患有细菌性败血症,被送往新生儿重症监护室.
- 纳入标准:阳性无菌部位培养物 (CSF或血液).
- 从2012年1月到2021年12月收集的数据,包括抗菌素敏感性测试.
主要成果:
- 晚发性败血症 (LOS) 的发生率 (94.43%) 显著超过早期发性败血症 (EOS) (5.56%).
- 格拉姆阳性细菌 (59.2%) 比格拉姆阴性细菌 (40.8%) 更为普遍.
- 关键分离物包括凝血酶负型葡萄球菌 (CONS) (40.98%) 在LOS和B组链球菌 (GBS) (44%) 在EOS.
结论:
- 凝聚酶阴性葡萄球菌 (CONS) 对包括安皮西林和西林在内的几种抗生素的耐药性降低.
- 黄金葡萄球菌表现出对红红素和勒沃素的耐药性增加.
- 经验性抗生素疗法似乎足够用于常见的新生儿败血症病原体.
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