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Investigating Intestinal Barrier Breakdown in Living Organoids
Published on: March 26, 2020
慢性失眠障碍患者的肠道屏障损伤的标志物
Yixian Cai1, Di Gong2, Ting Xiang3
1Department of Psychiatry, Sleep Medicine Centre, The First Affiliated Hospital of Jinan University, Guangzhou, China.
患有失眠障碍的个体表现出肠道屏障功能受损,由血清标志物减少证明. 这种肠道屏障功能障碍可能会导致失眠的发展和进展,影响睡眠质量和情绪.
科学领域:
- 睡眠医学 睡眠医学
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
背景情况:
- 失眠症是一种常见的疾病,与肠道微生物群的改变有关.
- 这些肠道变化可能会损害肠道屏障的完整性,影响失眠的发病和进展.
研究的目的:
- 为了评估失眠障碍患者的肠道屏障损伤.
- 在失眠患者中评估肠道屏障功能的血清标志物.
主要方法:
- 用ELISA测量了45名失眠患者和30名健康对照者的血清中二氨酸氧化酶 (DAO),D-乳酸 (D-LA),肠脂肪酸结合蛋白 (I-FABP) 和内甲蛋白 (ET) 的水平.
- 斯皮尔曼相关性分析探索了肠道标记物和临床特征之间的关系.
主要成果:
- 失眠患者在情绪和睡眠尺度上得分明显高,在多睡眠图上睡眠质量较差.
- 在失眠组中,DAO,D-LA,I-FABP和ET的血清度显著降低.
- 肠道屏障标志物与睡眠效率正相关,与失眠严重程度和情绪障碍负相关.
结论:
- 慢性失眠症与肠道屏障功能受损有关.
- 失眠患者肠道屏障完整性的血清标志物减少表明肠道健康和睡眠障碍之间存在潜在联系.
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