相关实验视频

Updated: May 12, 2026

Development of an In Vitro Ocular Platform to Test Contact Lenses

Development of an In Vitro Ocular Platform to Test Contact Lenses

Published on: April 6, 2016

一种新的Ex Vivo闪方法,用于比较新香配方的角质停留时间

Markus Glaudo¹, Marc Urbach^1,2, Claudia Panfil¹

¹Aachen Centre of Technology Transfer in Ophthalmology (ACTO e.V.), Aachen, Germany.

Alternatives to laboratory animals : ATLA

|April 12, 2024

概括

一个新的系统模拟眼睛暴露在洗发水中,测量它们从角膜清除的速度. 这有助于通过比较角膜清除时间来评估化品的眼睛安全性.

科学领域:

眼科医生眼科眼科
化品科学化品科学
毒理学毒理学毒理学

背景情况:

洗发水等化品存在意外暴露眼睛的风险.
长时间接触角膜是潜在的眼睛损伤的一个关键因素.

研究的目的:

开发和验证一种用于模拟角膜暴露在眼和眼流的新系统.
为了比较各种粘性洗剂配方,特别是洗发水的角膜清除时间.

主要方法:

使用ex vivo眼部刺激测试 (EVEIT) 框架与子角膜扩展器.
开发了一种片擦拭膜来模拟眼,以及一个模拟眼流动的流体系统.
测试了六种不同的洗发水配方,以确定它们的角膜清除特性.

主要成果:

在测试的洗发水配方中观察到角膜清除时间的显著差异.
配方被分为三个清除组:快速,中等和缓慢.
与所有其他配方相比,参考洗发水表现出最短的角膜清除时间.

结论:

开发的系统有效地模拟了眼睛暴露条件,使得可以测量角膜清除时间.
该方法为评估化品产品开发中的眼部安全的重要物理化学参数提供了有价值的工具.
了解角膜清除对于制定更安全的化品至关重要.

关键词:

体眼睛刺激测试试验人造眼的动作人造眼的动作闪闪闪闪在角膜角膜角膜是一个眼皮的眼皮眼睛的眼皮.眼的流动流动.

更多相关视频

In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition

In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition

Published on: August 20, 2016

Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation

Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation

Published on: May 2, 2020

相关概念视频

In Vitro Drug Dissolution: Compendial Testing Models II

In Vitro Drug Dissolution: Compendial Testing Models II

Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...

In Vitro Drug Dissolution: Alternative Methods

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...