硫酸三醇的功能性质和护肤效果
Kazuhisa Maeda1, Zheng Zhou2, Miao Guo2
1School of Bioscience and Biotechnology, Tokyo University of Technology, Hachioji, Tokyo, Japan.
概括
低分子量硫化寡糖类,如三硫酸盐,增强皮肤屏障功能和水分. 这些化合物通过增加关键屏障蛋白和天然保湿因素来改善皮肤,有效治疗干燥皮肤.
科学领域:
- 皮肤病学和化品科学
- 皮肤屏障功能研究研究 皮肤屏障功能研究
- 皮肤的分子生物学
背景情况:
- 肝类药物改善皮肤,但由于高分子量 (>5000) 的原因,透能力较差.
- 需要较小的肝类衍生物才能透到角层,以提高疗效.
- 了解皮肤屏障和保湿机制对于化品开发至关重要.
研究的目的:
- 评估硫酸寡糖 (<2000分子量) 对人类皮肤屏障和保湿功能的有效性.
- 研究这些化合物对参与皮肤水分和屏障完整性的关键蛋白质的影响.
- 为了确定硫酸三糖是否可以改善干燥皮肤状况.
主要方法:
- 使用3D人体表皮模型测量局部应用后的皮层间流失水 (TEWL).
- 通过RT-qPCR对与脂质运输 (ABCA12) 和自然保湿因子 (FLG) 相关的蛋白质的量化mRNA水平.
- 在干燥皮肤的参与者身上进行了一项随机的,安慰剂控制的双盲研究,在使用产品4周后评估TEWL和角层水含量.
主要成果:
- 观察到ABCA12,FLG,caspase-14,calpain-1和白胺酸酶的mRNA水平增加.
- 在3D皮肤模型中,硫酸三酸盐的应用提高了ABCA12,胺,转胺酶1和FLG水平.
- 临床研究显示,使用三硫酸盐制剂的参与者中,TEWL降低和角层水含量增加.
结论:
- 含有三硫酸的化品增强了表皮屏障和保湿因素.
- 这些化合物通过作用于表皮,有效地改善干燥皮肤状况.
- 硫酸三酸盐是护肤品的有希望的成分,其目标是修复屏障和补水.
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