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抗逆转录病毒药物和体重变化:权衡证据

David Alain Wohl¹, John R Koethe², Paul E Sax³

¹Institute of Global Health and Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

|April 12, 2024

概括

对人类免疫缺陷病毒 (HIV) 的抗逆转录病毒治疗可以影响体重. 与其他疗法相比,整合酶链转移抑制剂和tenofovir alafenamide fumarate可能与更大的体重增加有关.

科学领域:

传染性疾病传染性疾病
药理学药理学是指药理学的学科.
代谢过程中的代谢.

背景情况:

体重受个人和环境因素的影响.
在患有人类免疫缺陷病毒 (HIV) 的人群中,体重变化与疾病状况和抗逆转录病毒疗法 (ART) 有关.
减肥可以伴随艾滋病毒的进展,并且可以通过有效的ART逆转.

研究的目的:

审查暴露前预防 (PrEP) 和艾滋病毒治疗的主要随机试验中的体重变化.
要突出评估ART在体重变化中的作用的挑战.
提出一个模型,质疑某些ART与过度体重增加之间的关联.

主要方法:

关于涉及PrEP和HIV治疗的主要随机对照试验的综述.
分析不同抗逆转录病毒药物疗法的体重变化.
检查整合酶链转移抑制剂 (INSTIs) 和其他ART剂之间的比较数据.

主要成果:

在ART试验中的体重变化因治疗方案而异.
使用杜洛特格拉维尔和比克特格拉维尔观察到更大的体重增加,特别是使用诺福维尔阿拉芬胺胺酸 (TAF).
含有特诺福维尔二氧化 fumarate (TDF) 的疗法与较少的体重增加有关.

结论:

关于INSTIs和TAF导致过度体重增加的假设需要重新评估.
ART疗法,特别是INSTI和TAF,影响了艾滋病毒感染者的体重变化.
关于艾滋病毒治疗的临床决策应仔细考虑与ART相关的体重变化.

关键词:

抗逆转录病毒治疗 (ART)临床试验是指临床试验中的临床试验.暴露前预防 (PrEP)体重变化体重变化体重增加体重增加

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