对于晚期/复发性子宫内膜癌的阿特佐利祖马布加化疗的成本效益
Gengwei Huo1,2,3,4, Ying Song5, Peng Chen1,2,3,6
1Department of Thoracic Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Journal of gynecologic oncology
|April 12, 2024
概括
对于晚期子宫内膜癌 (EC) 来说,阿特佐利祖马布加化学疗法是不具有成本效益的. 然而,将阿特佐利祖马布治疗限制在两年,提高了dMMR EC患者的成本效益.
科学领域:
- 在瘤学瘤学.
- 卫生经济学 卫生经济学
- 临床试验 临床试验
背景情况:
- 晚期或复发的子宫内膜癌 (EC) 存在重大治疗挑战.
- 目前的治疗模式需要持续评估成本效益.
研究的目的:
- 从美国付款人的角度来评估阿特佐利祖马布与晚期或复发性EC的化疗相结合的成本效益.
- 在不匹配修复缺陷 (dMMR) 和不匹配修复专业 (pMMR) 的EC子组中评估成本效益.
主要方法:
- 基于ENGOT-en7/MaNGO/AtTEnd临床试验数据开发了一个马尔科夫模型.
- 模拟对比了阿特佐利祖马布加化学疗法与单独化学疗法.
- 使用15万美元/QALY的支付意愿值来确定成本效益.
主要成果:
- 在dMMR EC中,阿特佐利祖马布产生了3.31个QALY,额外成本为855,042美元 (ICER:258,391美元/QALY).
- 在pMMR EC中,阿特佐利祖马布产生了0.50个QALY,额外成本为140,502美元 (ICER:279,240美元/QALY).
- 在dMMR EC中对阿特佐利祖马布的2年限值导致ICER为70,696美元/QALY,在WTP值内.
结论:
- 阿特佐利祖马布和化疗的结合通常不是高级或复发性EC的成本效益.
- 对dMMREC患者来说,阿特佐利祖马布治疗的有限持续时间 (最长2年) 可能会提高成本效益.
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