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儿童强化跨学科疼痛治疗后的大脑功能和疼痛干扰

Spencer Epp¹, Andrew Walker¹, Elodie Boudes²

¹Department of Anesthesiology, Perioperative and Pain Medicine.

The Clinical journal of pain

|April 12, 2024

概括

强化跨学科疼痛治疗 (IIPTs) 降低了慢性疼痛青少年中部额头 (MFG) 对情绪刺激的激活. 这种大脑变化与疼痛干扰的减少相关,这表明MFG是潜在的治疗生物标志物.

科学领域:

神经科学是一个神经科学.
心理学心理学心理学
儿科医学儿科医学

背景情况:

患有慢性疼痛的青少年往往会对情绪刺激产生改变的大脑反应.
强化跨学科疼痛治疗 (IIPTs) 旨在改善严重慢性疼痛的年轻人的功能.
在儿科慢性疼痛群体中,IIPT后的神经变化尚未得到充分理解.

研究的目的:

在患有慢性疼痛的青少年中,研究IIPT后对情绪刺激的反应中大脑活动的变化.
为了确定IIPT是否会改变大脑对情绪刺激的反应.
为了检查大脑活动变化与疼痛干扰之间的关联.

主要方法:

功能性磁共振成像 (fMRI) 用于扫描20名青少年 (年龄14-18岁) 在IIPT前后患有慢性疼痛.
参与者在fMRI期间看到了情绪 (快乐/恐惧) 和中性面部表情.
疼痛干扰在治疗前和治疗后被评估,统计分析检查了大脑激活变化及其与疼痛结果的相关性.

主要成果:

在IIPT后,对情绪刺激 (与对照图像相比) 的中额头 (MFG) 激活显著下降.
在IIPT后较低的MFG激活与减少疼痛干扰显著相关.
这些发现在14-18岁的青少年中观察到,他们患有慢性疼痛.

结论:

与假设相反,IIPT导致对情绪刺激的反应减少了MFG激活.
减少MFG激活与减少疼痛干扰有关,这表明一种新的治疗途径.
甲基可以作为治疗反应的潜在生物标志物,以及慢性疼痛管理未来干预措施的目标.

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