探索产前暴露于化化合物及其与出生结果的关系,使用非目标分析
Huan Lin1, Wei Gao1, Jingjing Li1
1Department of Occupational Health and Environmental Health, School of Public Health, Qingdao University, Qingdao 266071, China.
Environmental science & technology
|April 12, 2024
概括
在血中暴露于化和化化有机化合物 (Cl/Br-HOCs) 可能会影响胎儿的生长. 这项研究确定了新的Cl/Br-HOCs,并发现混合物暴露与新生儿长度的减少有关,这表明胎儿生长限制的风险.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 围产期健康 围产期健康
背景情况:
- 化有机化合物 (HOCs),特别是化和化 (Cl/Br-HOCs),是具有已知的毒性和生物积累的持久性环境污染物.
- 关于胎盘转移和与新型Cl/Br-HOCs相关的潜在不良分娩结果的数据有限.
研究的目的:
- 在人类带血液中识别和量化新型Cl/Br-HOCs.
- 研究单个和混合暴露于Cl/Br-HOCs与新生儿不良分娩结果之间的关联.
主要方法:
- 在2017-2022年期间收集的326个带血样本中使用非标方法来识别44个Cl/Br-HOCs.
- 多重线性回归 (MLR) 和贝叶斯核机器回归 (BKMR) 模型分析了Cl/Br-HOCs和出生结果 (出生体重,长度,权衡指数) 之间的关系.
主要成果:
- 在带血液中首次报告了几种Cl/Br-HOCs的存在,包括克洛桑特尔和氧尼尔.
- 个体甲暴露显示出与出生长度的暂时负相关性,在纠正后失去意义.
- BKMR分析显示,Cl/Br-HOCs混合物暴露与新生儿出生时间缩短之间存在显著的关联,这表明可能存在胎儿生长限制.
结论:
- 这项研究概述了生命早期的Cl/Br-HOC暴露组.
- 在带血液中暴露于Cl/Br-HOC的混合物与不良出生结果有关,特别是胎儿生长减少,突出了潜在的风险.
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