剂量策略的修改 (AUC或低谷) 对与米素与皮佩拉西林/塔扎巴克坦或塞菲皮姆和美罗胺结合的AKI的影响

Breanne Mefford1,2, Katie L Wallace1,2, J Chris Donaldson1,2

  • 1Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, Kentucky, USA.

概括

与塞费皮姆/美罗烯姆相比,使用皮佩拉西林-塔扎巴克坦 (TZP) 与万科米辛 (VAN) 增加了急性损伤 (AKI) 的风险. 范科米辛的监测策略 (AUC与低谷) 并没有改变这种AKI风险. 在不同组中,MAKE-30的结果是相似的.

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