Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Long-term Potentiation01:35

Long-term Potentiation

55.2K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
55.2K
Integration of Synaptic Events01:28

Integration of Synaptic Events

1.5K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
1.5K
Long-term Depression01:03

Long-term Depression

2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.5K
Chemical Synapses01:26

Chemical Synapses

8.8K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
8.8K
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

1.7K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.7K
Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

9.9K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
9.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Unreliable homeostatic action potential broadening in cultured dissociated neurons.

bioRxiv : the preprint server for biology·2025
Same author

Visual activity enhances neuronal excitability in thalamic relay neurons.

Science advances·2025
Same author

cAMP reduces action potential amplitude and conduction velocity over long axonal distance.

The Journal of physiology·2024
Same author

Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives.

Physiological reviews·2024
Same author

Monoallelic de novo <i>AJAP1</i> loss-of-function variants disrupt trans-synaptic control of neurotransmitter release.

Science advances·2024
Same author

High-Resolution Proteomics Unravel a Native Functional Complex of Cav1.3, SK3, and Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Midbrain Dopaminergic Neurons.

Cells·2024

相关实验视频

Updated: Jun 28, 2025

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System
09:51

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System

Published on: January 1, 2018

11.6K

在模拟-数字促进过程中,在没有突触延迟变化的情况下,增强释放概率.

Sami Boudkkazi1,2, Dominique Debanne2

  • 1Physiology Institute, University of Freiburg, 79104 Freiburg, Germany.

Cells
|April 12, 2024
PubMed
概括
此摘要是机器生成的。

在脱极化诱导的模拟数字便利化 (d-ADF) 过程中,尽管突触前释放的概率增加,突触延迟仍然保持不变. 这表明,涉及行动潜力变化的补偿机制保持了精确的神经元定时.

关键词:
取决于上下文的便利化当地电路的局部电路.新皮质新皮质的新皮质神经系统的时间表.突触延迟时间 (synaptic latency) 是一个突触延迟时间.突触传输是突触传输的过程.

更多相关视频

Evaluation of Synaptic Multiplicity Using Whole-cell Patch-clamp Electrophysiology
10:52

Evaluation of Synaptic Multiplicity Using Whole-cell Patch-clamp Electrophysiology

Published on: April 23, 2019

12.9K
Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
09:39

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

26.9K

相关实验视频

Last Updated: Jun 28, 2025

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System
09:51

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System

Published on: January 1, 2018

11.6K
Evaluation of Synaptic Multiplicity Using Whole-cell Patch-clamp Electrophysiology
10:52

Evaluation of Synaptic Multiplicity Using Whole-cell Patch-clamp Electrophysiology

Published on: April 23, 2019

12.9K
Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
09:39

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

26.9K

科学领域:

  • 神经科学是一个神经科学.
  • 突触性可塑性 突触性可塑性
  • 计算神经科学是一种神经科学.

背景情况:

  • 神经元定时对于像感知和记忆这样的大脑功能至关重要.
  • 突触延迟受到突触前释放概率和动作潜力的波形的影响.
  • 现有的研究将突触延迟变化与各种形式的突触可塑性联系起来.

研究的目的:

  • 调查是否在脱极化诱导的模拟数字便利化 (d-ADF) 过程中调节了突触延迟.
  • 了解在d-ADF期间的突触延迟中释放概率和动作潜能动态之间的相互作用.

主要方法:

  • 来自金字塔式L5-L5细胞突触的电生理记录.
  • 通过长时间的突触前脱极化诱导d-ADF.
  • 对突触延迟,释放概率和动作潜能属性的分析.

主要成果:

  • 脱极化诱导的模拟-数字促进 (d-ADF) 提高了前突触释放概率 (Pr).
  • 尽管Pr升高,但在d-ADF期间,L5-L5细胞突触的突触延迟在d-ADF期间保持不变.
  • 在d-ADF中介的前突触Kv1通道的电压失活.

结论:

  • 由于补偿相互作用,d-ADF期间的突触时间不受影响.
  • 突触前释放概率和突触延迟的动作潜力依赖调制相互平衡.
  • 与其他可塑性形式不同,d-ADF保留了突触定时精度.