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在血性恶性瘤中对平分异性干细胞移植后的长期结果
Supawee Saengboon1,2, Stefan Ciurea3, Uday Popat1
1Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Blood advances
|April 12, 2024
概括
移植后的循环胺 (PTCy) 改善了平分相同干细胞移植 (haplo-SCT) 的结果. 在haplo-SCT后2年,活着且无疾病的患者显示出优异的长期存活率,年龄是唯一的负面预测因素.
科学领域:
- 血液学 血液学 血液学
- 移植免疫学 移植免疫学
- 在瘤学瘤学.
背景情况:
- 移植后的循环胺 (PTCy) 通过改善移植对宿主疾病 (GVHD) 预防,彻底改变了平分相同的干细胞移植 (haplo-SCT).
- 评估长期结果对于理解基于PTCy的哈普洛-SCT的持续有效性和安全性至关重要.
研究的目的:
- 为了回顾评估患者的长期生存和结果,他们接受了他们的第一个Haplo-SCT与基于PTCy的GVHD预防.
- 为了确定基于PTCy的Haplo-SCT后的长期成功和晚期并发症的预测因素.
主要方法:
- 对335名在2009年2月至2019年3月期间接受了Haplo-SCT的患者进行了回顾性分析.
- 长期幸存者被定义为在移植后2年内活着且没有疾病的人.
- 分析了无进展生存率 (PFS),总生存率 (OS),复发率和非复发死亡率 (NRM).
主要成果:
- 所有患者的整体4年PFS和OS分别为42%和47%.
- 长期幸存者 (2年活着,没有疾病) 显示出优秀的4年PFS (94%) 和OS (96%).
- 年龄≥55岁是劣质PFS和OS (P < .05) 的唯一显著预测因素. 晚期复发很少发生 (2.9%的累积发病率),二级原发性恶性瘤是非复发性死亡率的主要原因.
结论:
- 基于PTCy的Haplo-SCT为在移植后2年实现无病状态的患者提供了优异的长期生存率.
- 晚期复发不常见,而非复发死亡率在这个队列中很低.
- 年龄是一个关键因素,影响基于PTCy的Haplo-SCT的长期结果.
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