在被监禁人口中比较宫癌查策略
Anna Caroline Cochrane1, Brooke W Bullington2,3, Caroline Prokopowicz4
1Department of Obstetrics and Gynecology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA.
Journal of women's health (2002)
|April 12, 2024
概括
在被监禁妇女的宫癌查发现,细胞学和联合测试比单独的hrHPV测试更有效地检测出癌前症 (CIN2+). 这凸显了在这种高风险,低选人群中进行量身定制查的必要性.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 监禁人口代表了一个高风险,低选的宫癌群体.
- 宫内皮质瘤 (CIN) 和高风险的人类乳头瘤病毒 (hrHPV) 感染是这群人群的重大问题.
- 目前的宫癌查指南可能对被监禁的人来说并不理想.
研究的目的:
- 确定被监禁妇女中CIN,hrHPV感染和宫癌的流行率.
- 评估当前宫癌查方法在检测宫癌前期癌症 (CIN 2/3) 中的表现.
主要方法:
- 对已删除的细胞学,hrHPV DNA 和组织病理学活检数据的回顾性分析.
- 数据与人口统计信息的链接,用于北卡罗来纳州妇女惩戒机构 (2013-2020) 的监禁人员.
- 查测试性能的流行差异和置信区间的计算.
主要成果:
- 在15319人中,有18%的人有异常的宫细胞学;24.3%的人有阳性hrHPV检测.
- 细胞学和联合测试检测到CIN2+的比率更高 (95.9%和96.5%),而不是初级HRHPV测试 (89.9%).
- 对于CIN3+的检测率显示了类似的趋势,细胞学和联合测试的表现相似.
结论:
- 初级细胞学和联合测试表明,在这种被监禁人群中,与初级hrHPV测试相比,CIN2+的检测优越.
- 调查结果强调,被监禁的人并不是平均风险,需要考虑适应查策略.
- 查协议应重新评估,以更好地满足被低查,高风险监禁群体的独特需求.
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