自然药用植物活性成分在口腔状细胞癌中的应用
Qun-Li Ren1,2, Xiao-Lan Li1,2, Tian Tian3
1School of Stomatology, Zunyi Medical University, Zunyi, Guizhou Province, 563000, China.
Chinese journal of integrative medicine
|April 12, 2024
概括
天然药用植物活性成分 (NMPAI) 在治疗口腔状细胞癌 (OSCC) 方面表现有前途. 这些化合物抑制癌症生长,诱导细胞死亡,调节免疫力,为这种具有挑战性的癌症提供了潜在的新疗法途径.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 口腔状细胞癌 (OSCC) 是一种普遍存在的头癌,患者的预后不佳,尽管采用了放射治疗,化疗和手术等常规治疗方法,但复发率很高.
- 全球OSCC的发病率将其列为全球第六个最常见的癌症,强调迫切需要新的治疗策略.
研究的目的:
- 审查天然药用植物活性成分 (NMPAI) 对口腔状细胞癌 (OSCC) 的多样性影响.
- 阐明NMPAI的类型,它们的抗癌机制,相关的信号通路,以及与OSCC治疗相关的临床试验结果.
主要方法:
- 对研究NMPAI及其对OSCC的影响的综合文献综述.
- 对已识别的NMPAI进行分析,包括特类,类,黄类,葡萄糖类,类,类和挥发性油类.
- 检查抗癌机制,信号通路 (例如,MAPK,PI3K/AKT,NF-κB,miR-22/WNT1/β-catenin,Nrf2/Keap1),以及临床证据.
主要成果:
- NMPAI对OSCC表现出多方面的抗癌作用,包括抑制增殖,诱导亡和自,抑制迁移和入侵.
- 这些化合物调节关键的癌症相关信号通路,并表现出调节抗瘤免疫力的潜力.
- 临床发现表明,NMPAI可以抑制OSCC的生长,组合疗法显示出增强的疗效.
结论:
- 天然药用植物活性成分是开发口腔状细胞癌新疗法的有希望的来源.
- 需要进一步的研究和临床试验,以充分探索NMPAI在OSCC管理中的治疗潜力.
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