Lysophosphatidylserine:一种信号脂质,对人类疾病有影响
Arnab Chakraborty1, Siddhesh S Kamat1
1Department of Biology, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pashan, Pune 411008, Maharashtra, India.
Chemical reviews
|April 12, 2024
概括
lysophosphatidylserine (lyso-PS) 是哺乳动物的一个重要信号脂质. lysos-PS代谢的失调与自身免疫和神经系统疾病有关,这突显了它在人类健康中的关键作用.
科学领域:
- 生物化学 生化学
- 分子生物学分子生物学
- 人体生理学 人体生理学
背景情况:
- lysophosphatidylserine (lyso-PS) 是哺乳动物中一个关键的信号溶解脂.
- 它的新陈代谢对于各种生物过程至关重要,细胞水平受到严格调节.
- 异常的lysos-PS代谢与人类自身免疫和神经系统疾病有关.
研究的目的:
- 综合审查lysophosphatidylserine的结构,新陈代谢,信号和疾病关联.
- 探索由lysos-PS.调节的生物化学活动和受体.
- 讨论未来的研究方向在lysos-PS介导哺乳动物生理学.
主要方法:
- 文献综述总结了对lysophosphatidylserine的现有研究.
- 对合成类型的生物化学途径,受体相互作用和结构-活性关系 (SAR) 的分析.
- 讨论临床影响和疾病关联.
主要成果:
- Lysophosphatidylserine 在哺乳动物生理学中起着不可或缺的作用.
- 解调lysos-PS代谢与一系列人类疾病有关.
- 有大量关于lysos-PS的文献,涵盖其合成,信号和生物活动.
结论:
- Lysophosphatidylserine 是一种关键的信号分子,对人类健康有重大影响.
- 对lysos-PS代谢和信号通路的进一步研究是有必要的,以了解和治疗相关疾病.
- 了解lysos-PS介导的生理学对推进治疗策略具有前景.
相关概念视频
01:35Asymmetric Lipid Bilayer
7.2K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
7.2K
01:27Synthesis of Phosphatidylcholine in the ER Membrane
3.1K
The ER synthesizes lipids for building cell membranes and performing cellular functions such as energy storage and signaling. The lipid synthesis machinery embedded in the ER membrane primarily collects all reactants from the cytosol. Following synthesis, the secretory pathway and the ER contact sites distribute these lipids to other cellular organelles. Additionally, the energy-rich triacylglycerides are transported from the ER via lipid droplets.
The major components of all eukaryotic cell...
The major components of all eukaryotic cell...
3.1K
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
156
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
156
01:32Membrane Lipids
23.9K
Lipids are an essential component of all biological membranes. The average lipid content in mammalian membranes is 50%, though it can be as low as 20% in the inner mitochondrial membrane or as high as 80% in the myelin sheath present around the nerve cells.
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...
23.9K
01:42Phosphoinositides and PIPs
8.5K
Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
8.5K
01:31Lipid-derived Compounds in the Human Body
4.4K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.4K