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Updated: Jun 28, 2025

Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics
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Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics

Published on: June 23, 2022

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C. elegans 普雷西尼林 调解器官间接触和通信,这是溶酶体活动所需的

Kerry C Ryan1, Zahra Ashkavand1, Jocelyn T Laboy1

  • 1Department of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, New York 12208 USA.

Aging and disease
|April 12, 2024
PubMed
概括

与阿尔茨海默病相关的普列尼林突变通过改变信号来破坏溶酶体功能. 这项研究揭示了SEL-12蛋白质维持了溶酶体的酸性和健康,这对神经保护至关重要.

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In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay

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相关概念视频

Lysosomes01:31

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Lysosomes are membrane-enclosed spherical sacs derived from the Golgi apparatus. The most important function of the lysosome is degrading macromolecules and biological polymers that are released during membrane trafficking events such as the secretory, endocytic, autophagic, and phagocytic pathways. The degradation is carried out by several hydrolytic enzymes active in an acidic environment of the lysosomal lumen. These acid hydrolases are involved in cellular processes such as cell signaling,...
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Intralumenal Vesicles and Multivesicular Bodies

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ER Retrieval Pathway

In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
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Export of Misfolded Proteins out of the ER

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Lysosomal Hydrolases

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Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
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