患有痴呆症患者的发病率和危险因素:使用乌姆比亚地区医疗保健数据库进行的一项基于人口的研究
Cinzia Costa1, Elena Nardi Cesarini1,2, Paolo Eusebi1
1Department of Medicine and Surgery, Neurology Clinic, University of Perugia, S.M. Misericordia Hospital, Perugia, Italy.
Journal of Alzheimer's disease : JAD
|April 12, 2024
概括
痴呆症显著增加患的风险,特别是在男性和早期痴呆症患者中. 医疗保健提供者应对痴呆症患者的症状保持警.
科学领域:
- 神经学 神经学
- 老年病的医生 老年病的医生
- 流行病学 流行病学
背景情况:
- 痴呆症在老年人中很常见,并且与风险增加有关.
- 在痴呆症患者中发病率的估计是有限的.
研究的目的:
- 为了确定痴呆症患者发病的发生率.
- 在乌姆布里亚地区的痴呆症患者中识别与相关的危险因素.
主要方法:
- 使用乌姆布里亚 (2013-2017) 的医疗保健行政数据进行的回顾性研究.
- 使用ICD-9-CM代码识别的痴呆病例.
- 经验证的确定算法需要EEG和抗药物处方后痴呆症诊断.
- 使用考克斯比例危险模型进行病例控制分析.
主要成果:
- 确定了7314例痴呆病例和35280例对照病例.
- 痴呆症患者的发病率为2.02% (148例).
- 随着时间的推移,痴呆症诊断后,发作的累积发病率增加.
- 痴呆症显著增加了风险 (HR=4.58).
- 男性性别和痴呆发病时年龄较小是额外的危险因素.
结论:
- 痴呆症是发作的重要危险因素.
- 早期发病的痴呆症和男性性别与更高的风险有关.
- 临床医生应该考虑在痴呆症患者出现发作时的.
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