身体,大脑,环境和帕金森病
E Ray Dorsey1, Briana R De Miranda2, Jacob Horsager3
1Department of Neurology and Center for Health and Technology, University of Rochester Medical Center, Rochester, NY, USA.
Journal of Parkinson's disease
|April 12, 2024
概括
环境中有毒物质可能会引发像帕金森病这样的利维体疾病. 吸入或摄入的毒素可以在鼻子或肠道中启动α-synuclein病理,可能导致大脑或身体第一疾病亚型.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 勒维体疾病,包括帕金森病和勒维体痴呆症,以聚合的α-synuclein病理为特征.
- 目前的模型表明病理始于嗅觉系统 (大脑第一) 或肠道神经系统 (身体第一).
- 这两种系统都与外部环境连接,涉及环境因素.
研究的目的:
- 建议吸入或摄入的环境有毒物质是莱维体疾病的可信触发因素.
- 将环境暴露纳入现有的脑第一和身体第一模型.
- 关于疾病流行,发病率和病理特征的可测试假设.
主要方法:
- 对现有的勒维体疾病模型进行审查和综合.
- 假设有毒物质进入的途径 (通过鼻子吸入,通过肠道摄入).
- 将有毒物质暴露与α-synuclein病理和随后的传播联系起来.
主要成果:
- 吸入的有毒物质可能会导致嗅觉系统的α-synuclein病理,导致大脑首先出现的莱维体病.
- 摄入的有毒物质可能会导致肠道神经系统的α-synuclein病理,导致体为首的Lewy体疾病.
- 这个框架为疾病特征和进展产生可测试的假设.
结论:
- 通过鼻子和肠道暴露的环境被认为是勒维体疾病的关键发起者.
- 这种相互作用可能解释帕金森病和相关痴呆症的病因.
- 需要进一步的研究来解决局限性问题,包括皮肤和微生物组的作用,并朝着预防迈进.
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