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尿中瓦宁-1作为在外周动脉疾病中生存的新生物标志物
Bernhard Zierfuss1, Anna Karlinger1, Marija Bojic2,3
1Medicine II, Division of Angiology, Medical University of Vienna, Vienna, Austria.
Vascular medicine (London, England)
|April 12, 2024
概括
尿中素-1 (uVNN1) 可能有助于预测患有外周动脉疾病 (PAD) 的患者的死亡风险. 这种损伤标志物可以对患有PAD和早期病的人进行分层结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 生物标志物发现发现
背景情况:
- 慢性病 (CKD) 显著增加了周围动脉疾病 (PAD) 患者的发病率和死亡率.
- 目前还没有确立PAD早期病的特定功能风险评估标志物.
- 尿液中素-1 (uVNN1) 是氧化应激和早期损伤的标志物,被提出作为潜在的风险分层工具.
研究的目的:
- 调查尿路宁-1 (uVNN1) 与患有外围动脉疾病 (PAD) 的患者死亡率的相关性.
- 评估uVNN1作为一种潜在的生物标志物,用于PAD患者的分层风险,同时患有脏疾病.
主要方法:
- 一项前性研究对304名稳定的PAD患者进行了长达10年的跟踪.
- 用ELISA测量尿液中瓦宁-1 (uVNN1) 水平,并将其正常化为尿液中的肌氨酸 (uVNN1/Cr).
- 所有原因和心血管死亡率通过中央死亡数据库查询进行评估,并使用卡普兰-梅尔曲线和考克斯回归分析.
主要成果:
- uVNN1/Cr与尿中的白蛋白-肌素比率 (UACR) 相对相关,但没有估计的淋巴细胞过率 (eGFR).
- 较高的uVNN1/Cr水平与所有原因和心血管死亡率的增加显著相关.
- 多变量考克斯回归证实uVNN1/Cr是PAD患者死亡率的独立预测因子.
结论:
- 尿中素-1 (uVNN1) 独立地与PAD患者的全因和心血管死亡率有关.
- uVNN1显示为一种有价值的生物标志物,可用于PAD患者的风险分层,特别是早期病患者.
- 这一发现可能会为患有脏并发症的PAD患者改善管理策略.
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