克洛扎治疗神经发育障碍的青少年的攻击性行为
Stefano Berloffa1, Gabriele Masi1, Francesca Falcone1,2
1IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Calambrone, Italy.
Journal of child and adolescent psychopharmacology
|April 12, 2024
概括
克洛扎有效地治疗了患有神经发育障碍的青少年的侵略性,显示出行为和功能显著改善. 增加食欲和腹等副作用是可以控制的,但观察到的严重不良事件很少.
科学领域:
- 儿童和青少年精神病学 儿童和青少年精神病学
- 神经发育障碍 神经发育障碍
- 药理学 药理学是指药理学的学科.
背景情况:
- 患有神经发育障碍 (NDD) 的年轻人的侵略性带来了重大挑战.
- 治疗耐药性很常见,需要探索替代药物疗法.
- 第二代抗精神病药 (SGA) 经常被使用,但有效性可能是有限的.
研究的目的:
- 评估克洛扎宾在NDD中对侵略性的有效性和耐受性.
- 评估克洛沙对行为失控和功能障碍的影响.
- 为了确定与克洛沙治疗相关的常见副作用和缓解率.
主要方法:
- 一组26名青少年 (8-18岁) 患有ASD和/或ID/边缘认知功能和严重的攻击性被用克洛扎治疗.
- 患者至少在之前的两次SGA试验中失败.
- 使用CGI尺度,CGAS和ABC衡量有效性;随访时间至少为6个月.
主要成果:
- 在临床严重程度 (CGI-S),功能障碍 (CGAS) 和异常行为 (ABC总分) 中观察到显著改善.
- 超过60%的患者对克洛扎宾有反应,其中50%的患者实现了异常行为的缓解.
- 常见的副作用包括食欲增加,腹和重复性行为;没有白血病症等严重不良事件.
结论:
- 克洛扎似乎是对患有NDD的年轻人治疗耐药性侵略的可行选择.
- 该药物在减少侵略性和改善整体功能方面表现出显著的有效性.
- 在治疗期间应考虑常见副作用的管理策略.
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