皮层-大脑协调促进神经假肢的控制.
Aamir Abbasi1, Rohit Rangwani1,2, Daniel W Bowen1
1Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Science advances
|April 12, 2024
概括
小脑对于脑机界面 (BMI) 控制至关重要. 抑制小脑活动降低了神经假体任务的性能,证明了它对运动学习和控制的必要性.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 大脑与计算机的接口
背景情况:
- 跨大脑区域的时间协调的神经活动对行为至关重要.
- 我们对皮层和皮下相互作用如何控制复杂任务的理解有限.
- 大脑机器接口 (BMI) 提供了一个研究神经控制的模型.
研究的目的:
- 在BMI学习过程中,研究主要运动皮层 (M1) 和小脑之间的神经协调.
- 确定小脑活动在M1驱动的神经假肢控制中的作用.
- 阐明M1和小脑活动如何相互作用以支持学习行为.
主要方法:
- 训练大鼠进行神经假体任务,将M1活动与执行器运动联系起来.
- 分析M1与逆侧大脑皮层之间的局部场潜在 (LFP) 连贯性.
- 在任务执行期间,小脑皮层和深核的光遗传抑制.
- 在这两个区域检查与任务相关的神经刺.
主要成果:
- 在M1和小脑之间出现3-6Hz的LFP连贯性与学习.
- 通过小脑活动来调节与任务相关的学习-依赖调节.
- 在小脑内识别强大的,间接的与任务相关的调制.
- 小脑抑制导致M1驱动的神经假体控制的显著损害.
结论:
- 对于有效的M1驱动的神经假肢控制,小脑的影响是必不可少的.
- 小脑在BMI范式内在运动学习中发挥着必要的作用.
- M1和小脑之间的协调活动对于成功执行任务至关重要.
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