精神分裂症中奖励的自适应编码,随着时间的推移而发生的变化以及与冷漠的关系
Mariia Kaliuzhna1, Fabien Carruzzo1, Noémie Kuenzi2
1Clinical and Experimental Psychopathology Laboratory, Department of Psychiatry, University of Geneva, 1205 Geneva, Switzerland.
精神分裂症患者表现出受损的奖励处理,特别是他们的大脑如何适应不同的奖励量. 实践改善了患者的这种适应编码,但过度适应可能会使症状恶化.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 奖励的自适应编码涉及神经反应调整到可用的补偿范围.
- 精神分裂症与适应性编码的缺陷有关,特别是在奖励领域.
- 了解这些缺陷对于解决精神分裂症的动机症状至关重要.
研究的目的:
- 与对照人群相比,研究精神分裂症患者对奖励的自适应编码.
- 检查适应编码缺陷与临床症状之间的关联.
- 评估这些缺陷的纵向稳定性及其在不同实验场所的一致性.
主要方法:
- 使用功能磁共振成像 (fMRI) 和货币激励延迟任务.
- 参与者适应了狭窄和广泛的奖励范围.
- 兴趣区域分析侧重于条纹和视觉区域.
主要成果:
- 精神分裂症患者表现出适应编码的减少,这可以通过在条纹区域内的狭窄奖励范围的斜率下降来证明.
- 这一缺口在两个研究地点都是一致的.
- 重新测试显示患者的适应编码有所改善,而对照组显示略有下降;患者的过度坡与负面症状相关.
结论:
- 在精神分裂症中证实了奖励适应的缺陷.
- 实践可以改善患者的适应编码,尽管过度适应可能会损害奖励歧视,并导致动机症状.
- 在新鲜和熟悉的奖励环境中,神经反应精度的改变可能是精神分裂症的动机障碍的基础.
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