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Updated: Jun 13, 2026

A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation
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发现了SARS-CoV-2主要蛋白酶的第一类PROTAC降解剂

Yugendar R Alugubelli1, Jing Xiao1, Kaustav Khatua1

  • 1Texas A&M Drug Discovery Center, Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.

Journal of medicinal chemistry
|April 12, 2024
PubMed
概括

针对冠状病毒的主要蛋白酶 (MPro) 的新抗病毒药物显示出有希望. 这项研究展示了一种新的向金氏体的蛋白质分解 (PROTAC) 方法来降解MPro,为抗药性SARS-CoV-2变种提供了潜在的抗药性.

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