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双Z暴露通过破坏线粒体功能来抑制卵细胞中介成熟

Cong Ma¹, Yan Xu¹, Huilei Chen¹

¹Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei 230022, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, No.81 Meishan Road, Hefei 230032, China; Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People's Republic of China, No.81 Meishan Road, Hefei 230032, China.

Ecotoxicology and environmental safety

|April 12, 2024

概括

双Z (BPZ) 不是双A (BPA) 的安全替代品. BPZ通过引起氧化应激,DNA损伤和线粒体功能障碍来损害哺乳动物卵细胞成熟,导致不孕.

科学领域:

生殖毒理学生殖毒理学
内分泌学在内分泌学.
细胞生物学细胞生物学

背景情况:

由于内分泌干扰,双甲 (BPA) 的使用受到限制.
双Z (BPZ) 是一种常见的BPA替代品,环境和人类水平不断上升.
卵细胞质量对于成功怀孕至关重要,但BPZ的影响尚不清楚.

研究的目的:

为了比较BPZ和BPA对实验室小鼠卵细胞中介成熟的毒性影响.
调查BPZ诱导的卵细胞毒性的潜在机制.

主要方法:

在实验室小鼠卵细胞培养模型.
暴露于150微米的BPZ和BPA.
介质的评估,染色体对齐,F-actin,线粒体功能,氧化应激,DNA损伤和亡.

主要成果:

无论是BPZ还是BPA都破坏了螺旋组装和染色体对齐;BPZ显示出更强的毒性.
BPZ 损害了F-actin 盖的形成,线粒体功能 (膜潜能,ATP),并诱导了氧化应激.
BPZ造成了显著的DNA损伤,触发了早期卵细胞亡,并损害了 lysosomal 功能.

结论:

BPZ不是BPA的安全替代品.
通过线粒体功能障碍,氧化应激和DNA损伤,BPZ诱导卵细胞亡.
这些影响破坏了卵细胞的细胞骨组织,细胞循环的进展,并最终抑制了介质成熟.

关键词:

BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA 这是BPZ BPZ.介质变化 (Meiosis) 是一个过程.线粒体中的线粒体.卵细胞是卵细胞中的一个.

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