潜在的治疗选择对于腹腔疾病:关于当前证据的更新,从无质饮食到细胞治疗
Effat Noori1, Nader Hashemi2, Delsuz Rezaee3
1Department of Biotechnology, Faculty of Medicine, Shahed University, Tehran, Iran.
International immunopharmacology
|April 12, 2024
概括
病 (CD) 需要新的治疗方法,因为无质饮食 (GFD) 对一些人来说是失败的. 本综述探讨了新型疗法,如免疫疗法和纳米粒子,用于治疗腹腔疾病.
科学领域:
- 胃肠道学和免疫学
- 自身免疫性肠道病症研究研究
- 治疗创新 治疗创新
背景情况:
- 病 (CD) 是一种自身免疫性疾病,由摄入质引发.
- 在活跃的CD中,肠外表现很常见.
- 严格的无质饮食 (GFD) 是当前的标准治疗方法,但有2-5%的患者表现出不充分的反应.
研究的目的:
- 审查对于乳病的综合治疗策略.
- 探索超越GFD的新型和替代治疗方法.
- 涵盖一系列创新,包括饮食,酶,免疫和遗传疗法.
主要方法:
- 对当前和新兴的乳病治疗方法的文献综述.
- 分析创新的治疗策略.
- 方法的分类,包括饮食修改,酶疗法,免疫调节以及基因疗法和纳米粒子等先进方法.
主要成果:
- GFD是有效的,但对于一组患者来说具有挑战性和不足.
- 目前正在研究多种新型治疗途径.
- 这些包括质降解,减少肠道透性,免疫反应调节,TG2抑制,HLA-DQ2/8阻断和耐受性诱导.
结论:
- 新的治疗策略对于对GFD无反应的乳病患者至关重要.
- 基于抗原的免疫疗法,细胞和基因疗法以及基于纳米粒子的治疗方法显示出有前途.
- 需要采用多方面的方法来解决乳病管理中的未满足需求.
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