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设计用于体药物输送的生物启发的体三区合聚物: 2 - 生物评估

Moritz Beck-Broichsitter¹

¹Department of Pharmaceutics and Biopharmacy, Philipps-Universität, Marburg, Germany; Medical Clinic II, Department of Internal Medicine, Justus-Liebig-Universität, Giessen, Germany.

Colloids and surfaces. B, Biointerfaces

|April 12, 2024

概括

生物灵感的聚乳酸) 纳米颗粒涂有聚二甲基氧乙烯酸化胆,显示毒性和免疫反应降低. 这种zwitterionic涂层提高了纳米粒子性能,用于肺部和静脉输送.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
药物运输药物运输药物运输

背景情况:

聚 (乳酸) 纳米粒子是有希望的药物输送工具.
表面修饰对于提高纳米粒子性能和生物相容性至关重要.
兹威特基聚合物为生物材料应用提供了独特的特性.

研究的目的:

为增强药物输送开发和评价涂层聚[2-(甲基烯酸) 乙烯酸化胆]的聚 (乳酸) 纳米颗粒.
评估这些纳米颗粒在肺和静脉注射后的体内性能.
为了研究zwitterionic涂层对纳米粒子-生物分子相互作用和细胞反应的影响.

主要方法:

合成的多分子 (乳酸) 纳米粒子.
涂层纳米颗粒与聚[2-(methacryloyloxy) 乙烯酸化胆].
在体外评估细胞毒性,蛋白质吸附和补体激活.
肺部和全身传递的体内评估,包括药理动力学和生物分布研究.

主要成果:

采用zwitterionic涂层可以防止纳米粒子聚合,并降低细胞毒性.
涂层的纳米粒子表现出较低的蛋白质吸附和补充激活.
肺部给药没有干扰肺表面活性剂的功能和最小的炎症反应.
静脉注射导致循环半衰期延长和肝脏生物分布延迟.

结论:

聚乙烯酸) 涂层显著提高了聚乳酸) 纳米颗粒的生物相容性和性能.
采用Zwitterionic聚合物涂层的纳米粒子适用于肺部和全身药物输送.
这种涂层策略为开发先进的体药物递送系统提供了一个有希望的方法.

关键词:

生物启发的triblock共聚物静脉注射是通过静脉注射进行的.肺部的交付肺部的交付聚[2-(甲基烯酸) 乙烯酸酸化胆] 聚[2-(甲基烯酸) 乙烯酸酸]聚合物纳米粒子聚合物纳米粒子

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