在接受结肠镜检查的患者中,西普罗和普罗波的疗效和安全性:双盲,随机,受控试验
Shi-Hui Gao1, Qian-Qian Tang1, Chang-Ming Wang2
1The Dalian Medical University, Dalian, China; Department of Anesthesiology, People's Hospital of China Medical University (People's Hospital of Liaoning Province), Shenyang, China.
Journal of clinical anesthesia
|April 12, 2024
概括
齐普罗在结肠镜检查中取得了与普罗波相似的成功,但副作用较少. 这种新型麻醉剂可减少注射疼痛,呼吸抑制和低血压,在无痛结肠镜检查过程中提高患者的满意度.
科学领域:
- 麻醉学 麻醉学
- 胃肠病学 胃肠病学
- 临床药理学 临床药理学
背景情况:
- 普罗波是结肠镜检查的常见麻醉剂,但有心肺抑制和注射疼痛等副作用.
- 齐普罗是一种新型化合物,被提出作为用于镇静的普罗波的替代品.
- 评估西普罗对普罗波的安全性和有效性对于改善手术镇静至关重要.
研究的目的:
- 为了比较西普罗与普罗波在无痛结肠镜检查中的安全性和有效性.
- 确定西普罗在副作用和患者满意度方面是否比普罗波具有优势.
主要方法:
- 一个随机的临床试验是在一个单中心的三级医院进行的.
- 接受结肠镜检查的成年患者 (ASA I-II,BMI 18-30 kg/m2) 被随机分配为接受西普罗福或普罗福的镇静剂.
- 评估了结肠镜成功率,镇静开始和恢复时间,患者和内镜师的满意度以及不良事件.
主要成果:
- 在西普罗 (96.3%) 和普罗波 (97.6%) 之间没有观察到结肠镜成功率的显著差异.
- 西普罗的注射疼痛发生率显著降低 (0%与40.2%相比),呼吸抑制 (2.4%与13.4%相比) 和低血压 (65.9%与80.5%相比).
- 与propofol相比,患者报告对西普罗镇静的满意度更高.
结论:
- 齐普罗是一种可行的替代品,用于用于结肠镜镇静的propofol.
- 一剂0.4毫克/千克的西普罗的有效性相当于一剂2.0毫克/千克的普罗波.
- 与结肠镜检查中的普罗波相比,西普罗提供了更好的安全性和患者满意度概况.
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