自然提取物干预对前列腺癌的影响:系统性审查和网络元分析
Haotian Huang1, Jiao Qin2, Zhi Wen1
1Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
概括
单独或与一起使用的西利宾,通过降低前列腺特异抗原 (PSA) 和类似胰岛素的生长因子-1 (IGF-1) 水平,在治疗前列腺癌方面表现有前途. 需要进一步的研究来确认安全性.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 前列腺癌预防研究已经探索了饮食模式和天然提取物.
- 目前,关于天然提取物在缓解前列腺癌风险方面的疗效的证据不足.
- 缺乏可靠的证据阻碍了推天然提取物用于预防前列腺癌.
研究的目的:
- 进行网络元分析,评估天然提取物对前列腺癌的影响.
- 评估天然提取物对关键生物标记物的影响,包括前列腺特异性抗原 (PSA),IGFBP-3和IGF-1.
主要方法:
- 在Embase,PubMed,Cochrane图书馆和Web of Science数据库中进行系统的文献搜索,直到2023年12月.
- 28项符合条件的研究的网络元分析,涉及1566名患者和16种天然提取物治疗.
- 评估的结果包括PSA,IGFBP-3和IGF-1水平;使用积累排名 (SUCRA) 曲线的表面下排名的治疗效果.
主要成果:
- 与结合的西利宾在降低血清PSA水平方面表现出最高的疗效 (SUCRA 74%).
- 在降低血清IGF-1水平 (SUCRA 84.6%) 和IGFBP-3水平 (SUCRA 67.7%) 方面,西利宾单一治疗最有效.
- 在28项研究中,有12项报告了药物不良反应/事件 (ADR/ADE).
结论:
- 与安慰剂相比,Silybin单独或与一起使用可能会增强前列腺癌患者的治疗效果.
- 这些发现为考虑天然提取物治疗的前列腺癌患者提供了洞察力.
- 需要进一步调查,以确定这些天然提取物处理的安全性.
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