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膝关节骨关节炎中改变的静态和动态功能性大脑网络:休息状态功能磁共振成像研究:KOA中的静态和动态FNC

Shirui Cheng¹, Fang Zeng¹, Jun Zhou²

¹Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Acupuncture and Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Key Laboratory of Acupuncture for Senile Disease (Chengdu University of TCM), Ministry of Education, Chengdu 611137, China.

|April 12, 2024

概括

膝关节骨关节炎 (KOA) 患者表现出大脑功能网络连接 (FNC) 的改变. 静态FNC的这些变化可能为KOA和其他疼痛条件的潜在治疗点提供见解.

科学领域:

神经成像是一种神经成像.
神经科学是一个神经科学.
整形外科整形外科整形外科

背景情况:

膝关节骨关节炎 (KOA) 是一种导致疼痛和功能限制的退行性关节疾病.
了解中枢神经系统在KOA中的作用对于开发有效的治疗方法至关重要.
在各种慢性疼痛疾病中观察到功能网络连接 (FNC) 的改变.

研究的目的:

调查KOA患者和健康受试者 (HS) 之间静态和动态功能网络连接 (FNC) 的差异.
探索改变的FNC和KOA的临床症状之间的相关性.
为了确定KOA的潜在神经成像生物标志物.

主要方法:

在休息状态功能磁共振成像 (rs-fMRI) 中,对159名KOA患者和73名HS患者进行了功能磁共振成像.
使用组独立组件分析 (GICA) 识别了七个静止状态网络.
应用K-means集群分析来研究动态的FNC状态.

主要成果:

KOA患者在默认模式网络 (DM),视觉网络 (VS) 和小脑网络 (CB) 中显示出静态FNC的减少.
在KOA患者中,在皮下网络 (SC) 和VS之间观察到静态FNC的增加 (p <0.05,FDR修正).
动态FNC分析在不同的窗口大小中产生了不一致的结果,这表明组比较的潜在不稳定性.

结论:

患有KOA的患者在静态功能网络连接中表现出广泛的异常.
这些发现突显了静态FNC作为KOA生物标志物的潜力.
该研究为确定KOA和其他肌肉骨疼痛疾病的中枢神经系统治疗点提供了一个参考.

关键词:

动态功能网络连接能力动态功能网络连接独立组件分析独立组件分析膝关节骨关节炎是一种关节炎.磁共振成像技术磁共振成像技术静态功能网络连接性的连接.

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