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早期生命感染的负担和亚型增加了喘的风险

Julie Nyholm Kyvsgaard¹, Laura Marie Hesselberg², Rikke Bjersand Sunde¹

¹Copenhagen Prospective Studies on Asthma in Childhood, Department of Pediatrics, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Pediatrics, Slagelse Hospital, Slagelse, Denmark.

The journal of allergy and clinical immunology. In practice

|April 12, 2024

概括

患有感冒和肺炎等儿童早期感染的高负担会增加喘的风险. 减少这些感染可能有助于预防儿童喘,特别是在过敏儿童中.

科学领域:

儿童呼吸系统健康问题
传染病的流行病学传染病的流行病学.
喘病原发生的原因

背景情况:

生命早期的感染与喘的发展有关.
关于感染负担和喘亚型的数据有限.
了解这种联系对于初级预防至关重要.

研究的目的:

调查生命早期感染负担和喘风险之间的关联.
分析特定的感染亚型 (感冒,肺炎等). 和它们与喘的关系.
评估感染对10岁肺功能的影响.

主要方法:

对662名儿童进行的前性队列研究 (哥本哈根儿童喘前性研究2010).
感染 (感冒,桃体炎,中耳炎,肺炎,胃肠炎,发烧) 从0-3岁追踪.
纵向诊断的喘 (年龄3-10岁);在10岁时测量肺功能.

主要成果:

高感染负担 (中位数为16例) 与喘风险增加有关 (aOR=3.61).
感冒,肺炎,胃肠炎和发烧导致喘风险增加.
肺炎负担与下肺功能有关;感冒与过敏儿童喘风险较高有关.

结论:

在特定早期感染的高负担和儿童喘之间发现了显著的关联.
患有呼吸道过敏的儿童尤其容易受到伤害.
减少早期生命感染是儿童喘初级预防的潜在策略.

关键词:

喘喘是一种孩子孩子孩子孩子孩子孩子感染感染感染肺功能肺功能肺功能呼吸道过敏呼吸道过敏

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