努力-成本决策与精神分裂症和双相情感障碍的负面症状相关
Serhan Isıklı1, Aslıhan Bilge Bektaş1, Şule Tamer1
1Department of Psychiatry, Katip Celebi University Ataturk Education and Research Hospital, Izmir, Turkey.
Behavioural brain research
|April 12, 2024
概括
精神分裂症 (SCZ) 和双相情感障碍 (BP) 患者对奖励的动机降低,与负面症状有关. 在这些条件下,基于努力的决策可能是共同因素.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 负面症状,包括动机缺陷和减少目标导向行为,在精神分裂症 (SCZ) 和双相情感障碍 (BP) 中很突出.
- 了解这些症状的神经生物学基础对于开发有效治疗方法至关重要.
研究的目的:
- 通过跨诊断方法研究负面症状与努力分配与金钱奖励之间的关联.
- 为了比较SCZ,BP和健康对照 (HC) 患者的基于努力的决策.
主要方法:
- 使用奖励的努力-支出任务 (EEfRT) 来评估对货币奖励的努力分配.
- 采用通用估计方程模型来分析EEfRT选择行为.
- 使用简要负症状量表 (BNSS) 评估负症状.
主要成果:
- 与HC相比,SCZ和BP两家集团的货币奖励努力支出都较低.
- 负面症状的严重程度增加与两个诊断组的EfRT表现负相关.
- 在SCZ和BP患者中观察到金钱奖励的动机减少.
结论:
- 基于努力的异常决策是SCZ和BP中负面症状的潜在跨诊断因素.
- 这些发现凸显了这些疾病中共同存在的动机缺陷.
- 对基于努力的决策进行进一步的研究可以为治疗负面症状的治疗策略提供信息.
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