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使用基于白蛋白的纳米颗粒的组合策略,以实现协同抗风湿疗效和降低肝毒性

Jiao Li1, Xiqian Zhang2, Lihua Pan3

  • 1Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China; Key Laboratory of Advanced Technologies of Materials, Ministry of Education and School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.

International journal of pharmaceutics
|April 12, 2024
PubMed
概括

这项研究开发了一种新型的纳米颗粒系统,可同时提供甲醇 (MTX) 和糖酸 (GA),用于治疗类风湿性关节炎 (RA). 该系统增强了MTX在关节中的有效性,同时保护肝脏免受MTX引起的损伤.

关键词:
联合交付 联合交付肝毒性 肝毒性 肝毒性甲基甲酸二醇的使用方法类风湿性关节炎 类风湿性关节炎 类风湿性关节炎

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