感染SARS-CoV-2可能导致胰腺功能障碍
Wei Deng1, Linlin Bao1, Zhiqi Song1
1NHC Key Laboratory of Comparative Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, 100021, China.
Signal transduction and targeted therapy
|April 12, 2024
概括
COVID-19 感染可以导致胰腺细胞损伤和代谢障碍,增加糖尿病风险,特别是在老年人中. 接种疫苗有助于维持葡萄糖平衡.
科学领域:
- 内分泌学 在内分泌学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 新出现的证据将COVID-19和疫苗接种与糖代谢功能障碍和糖尿病风险增加联系在一起.
- SARS-CoV-2 对胰腺细胞的直接影响和随后的代谢后果需要进一步调查.
研究的目的:
- 为了研究SARS-CoV-2感染和接种疫苗的非人类灵长类动物 (NHPs) 和人类COVID-19患者的胰腺病变和糖代谢功能障碍.
- 为了阐明年龄在COVID-19感染后糖尿病风险中的作用.
主要方法:
- 从感染和接种疫苗的NHP和COVID-19患者的尸检组织的回顾性分析.
- 在胰腺细胞中检测病毒感染的多标签免疫光.
- 对代谢和炎症标志物的系统性蛋白质组学,代谢组学和生物化学分析.
主要成果:
- 在NHP和人类中观察到的异位和内分泌胰腺细胞的直接SARS-CoV-2感染.
- 受感染的成年NHPs显示代谢障碍,胰岛素耐药性和C-水平升高.
- 老年人感染NHPs表现出β细胞损失,岛屿粉症,缩,纤维化,炎症和严重的糖代谢功能障碍;疫苗接种保持了葡萄糖平衡.
结论:
- SARS-CoV-2 感染直接影响胰腺细胞,导致糖代谢功能障碍和糖尿病风险增加,特别是在老年人中.
- 年龄是后COVID-19糖尿病累积风险的一个关键因素.
- 接种疫苗对葡萄糖恒温有保护作用.
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