在东正教犹太妇女中对BRCA1/2基因测试进行决策辅助的试点研究
Meghna S Trivedi1, Haley Manley2, Haeseung Yi3
1Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, 161 Fort Washington Avenue HIP 10, New York, NY, 10032, USA. mst2134@cumc.columbia.edu.
Familial cancer
|April 12, 2024
概括
一个基于网络的决策辅助工具改善了BRCA1/2遗传测试知识,并减少了正统犹太妇女的冲突. 然而,该工具并没有增加基因测试的意图或完成率.
科学领域:
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
- 医疗信息学 医疗信息学
背景情况:
- 东正教犹太妇女有独特的社会文化和宗教因素影响BRCA1/2基因测试决策.
- 对遗传性乳腺癌和卵巢癌综合征进行基因检测的采用可能会受到社区特定因素的影响.
研究的目的:
- 评估基于网络的决策辅助 (DA) 对东正教犹太妇女的BRCA1/2基因测试意图和完成的影响.
- 评估暴露于DA后遗传测试知识和决策冲突的变化.
主要方法:
- 一项单臂试点研究涉及50名东正教犹太妇女,她们接受了基于网络的"RealRisks" DA.
- 在暴露后的基线,1个月和6个月进行了连续调查,以评估测试意图,知识和决策冲突.
- 用描述性统计数据分析了基线特征和随时间变化的研究措施.
主要成果:
- DA显著改善了BRCA1/2基因测试知识,并减少了决策冲突.
- 尽管知识和冲突有所改善,但基因测试的意图/完成在1个月内与基线相比并没有显著增加 (46.5%与54%相比).
- 参与者的人口统计数据包括平均年龄为43.9岁,70%的参与者认定为现代东正教.
结论:
- 虽然基于网络的DA增强了有关BRCA1/2遗传测试的知识和减少了决策冲突,但它并没有增加东正教犹太社区的测试采用率.
- 未来的干预措施需要直接参与社区特定的障碍,并从东正教犹太社区领导人那里获得投入,以提高基因测试的普及率.
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