妊娠期体重增加和后代体重发展之间的关联:根据母亲怀孕前的BMI而有所不同
Charlotte Barzen1, Mandy Vogel2,3, Wieland Kiess2,3
1LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Strasse 27, 04103, Leipzig, Germany. charlottebarzen@gmail.com.
Archives of gynecology and obstetrics
|April 12, 2024
概括
母亲怀孕前的体重和妊娠期间的体重增加显著影响孩子的体重发展. 超重/肥胖妇女有更大的婴儿的风险,而正常/体重不足的妇女有更大的婴儿的风险.
科学领域:
- 产科和妇科 产科和妇科
- 儿科内分泌学 儿科内分泌学
- 公共卫生 营养 公共卫生 营养
背景情况:
- 全球肥胖率的上升凸显了需要了解影响儿童体重的因素.
- 孕期体重增加 (GWG) 经常偏离推的指导方针,可能会影响后代的健康.
- 怀孕前的体重指数 (ppBMI) 是妊娠结果和儿童发育的关键因素.
研究的目的:
- 检查妊娠前BMI (ppBMI) 和妊娠期间体重增加 (GWG) 与儿童体重发展到5岁之间的关联.
- 调查GWG对婴儿体重的影响是否根据母亲的ppBMI而有所不同.
主要方法:
- 来自德国LIFE Child队列研究的数据分析,包括691对母婴对.
- 长度跟踪儿童体重,直到5岁.
- 用回归分析来评估母亲的ppBMI,GWG和儿童体重结果之间的关联.
主要成果:
- 在正常/体重不足的女性中,GWG与出生体重 (BW) 有积极的相关性,并增加了对孕期大婴儿 (LGA) 的风险.
- 在超重/肥胖女性中,GWG没有显著影响BW或LGA风险;这些女性对LGA婴儿的基线风险更高.
- 后代的体重趋势持续到生命的前五年.
结论:
- 母亲超重/肥胖可能会增加后代出生体重和幼儿体重的风险.
- 对于正常/体重不足的妇女来说,GWG似乎是对儿童体重发展更有影响的因素.
- 建议强调要达到正常的妊娠前体重,并注意GWG,以获得更健康的后代.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Pathophysiology of Diabetes
924
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
924
Obesity
495
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
495
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Genomic Imprinting and Inheritance
34.4K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
34.4K
Background and Environment Affect Phenotype
6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K


