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在接受手术治疗的结直肠癌患者中,肠道微生物群与免疫微环境的关联
Nayoung Han1, Hee Jin Chang2, Hyun Yang Yeo3
1Department of Pathology, Research Institute and Hospital, National Cancer Center, Gyeonggi-do, South Korea.
Pathology
|April 12, 2024
概括
肠道微生物群影响结肠直肠癌 (CRC) 免疫力. 在CRC患者中丰富的Bacteroides fragilis与一个相关联.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 结肠直肠癌 (CRC) 的进展受到瘤微环境和全身免疫的影响.
- 肠道微生物组在调节CRC中这些免疫反应中的作用仍然不完全理解.
研究的目的:
- 研究便微生物群组成与手术治疗结直肠癌患者的局部/全身免疫反应之间的关联.
- 探索特定细菌物种与免疫特征,生存结果和CRC炎症标志物之间的关系.
主要方法:
- 来自114名结直肠癌患者的便样本的16S rRNA基因测序.
- 使用CD3和CD8免疫组织化学评估瘤免疫微环境.
- 对遗传变异,微卫星不稳定性和全身炎症标志物的分析.
主要成果:
- 26%的CRC患者表现出具有高T细胞密度的"免疫类型"表型,与较低的血管淋巴细胞入侵和更长的存活率有关.
- 在免疫性CRC病例中,Bacteroides fragilis和Collinsella aerofaciens是普遍存在的;在非免疫病例中,Odoribacter splanchnicus和Phascolarctobacterium succinatutens是普遍存在的.
- 细菌菌 (Bacteroides fragilis) 丰富度与较短的无病生存时间相关,而高的C. aerofaciens流行率与高的格拉斯哥预后得分有关.
结论:
- 在肠道微生物组组成,瘤免疫微环境和结直肠癌的疾病进展之间存在显著的关系.
- 在CRC患者中丰富的Bacteroides fragilis与"冷免疫"瘤微环境和较差的生存结果有关.
- 特定的肠道细菌可以作为免疫反应和结直肠癌的预后的潜在生物标志物.
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