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修改后的自然循环允许为计划冷胚胎转移设置7天的窗口

Carlos Alonso-Mayo¹, Graciela Kohls¹, Samuel Santos-Ribeiro²

¹IVIRMA Global Research Alliance, IVIRMA Madrid, Madrid, Spain.

Reproductive biomedicine online

|April 12, 2024

概括

在修改后的自然周期 (mNC) 中,排卵触发时间可以灵活. 复合人类胆管性腺激素 (rHCG) 可以在13-22毫米之间的平均卵泡大小下施用,允许更简单的冷胚胎移植 (FET) 调度.

科学领域:

生殖内分泌学生殖内分泌学
辅助生殖技术辅助生殖技术

背景情况:

修改自然循环 (mNC) 是冷胚胎移植 (FET) 激素替代疗法的替代方案.
在mNC中,排卵触发通常在主导卵泡达到特定大小时使用复合人体胆性腺激素 (rHCG).

研究的目的:

研究是否可以更灵活地计划在多国公司中使用rHCG触发排卵.
为了确定在触发时的不同毛囊平均直径是否会影响mNC FET中的怀孕结果.

主要方法:

一个追溯的观察性研究3087个单冷芽细胞转移在mNC.
患者符合子宫内膜厚度≥7mm和血清孕激素<1.5ng/ml的标准.
触发时的毛囊平均大小被分为三组:13.0-15.9毫米,16.0-18.9毫米和19.0-22毫米.

主要成果:

在卵泡大小组之间,没有观察到怀孕率,临床怀孕率,植入率或流产率的显著差异.
持续的怀孕率显示出趋势,但在调整为植入前遗传测试和卵子捐赠后并不显著.
所有组的基线特征在所有组中都是相似的.

结论:

复合人类胆管性腺激素 (rHCG) 可以灵活地在mNC FET中施用,平均毛囊大小从13毫米到22毫米不等.
这种灵活性取决于足够的子宫内膜发育和低血清孕激素水平.
这些发现表明,FET调度的潜在窗口为6-7天,简化了临床实践.

关键词:

循环调度时间表宫内膜制备剂宫内膜制备剂在冷胚胎移植过程中,冷胚胎被移植.修改自然循环的修改自然循环.持续的怀孕率持续的怀孕率

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